The intron-containing transcript: an evolutionarily conserved characteristic of the genes orthologous to nxf1 (Nuclear Export Factor 1)

Autor:	L. A. Mamon, Ye. V. Golubkova, A. O. Prosovskaya, Sergei Kliver, V. R. Ginanova
Rok vydání:	2014
Předmět:	Genetics Alternative splicing Intron Biology Genome NXF1 GenBank natural sciences Animal Science and Zoology FlyBase : A Database of Drosophila Genes & Genomes Nuclear export signal Agronomy and Crop Science Gene
Zdroj:	Russian Journal of Genetics: Applied Research. 4:434-443
ISSN:	2079-0600 2079-0597
DOI:	10.1134/s2079059714050104
Popis:	The function of the nxf1 (Nuclear Export Factor 1) gene is the nuclear-cytoplasmic transport of most mRNAs. A characteristic feature of the nxf1 genes in animals belonging to different taxonomic groups is existence of an alternative transcript with a homologous intron referred to as a cassette intron. The following databases were used: GenBank (http://www.ncbi.nlm.nih.gov/); FlyBase (http://flybase.org/); and UCSC Genome (http://genome.ucsc.edu). To build secondary structures of nucleotide sequences we used a UNAFold v3.8 suite (http://mfold.rna.albany.edu/). The nxf1 cassette introns form characteristic secondary structures. The paper discusses the possible functional significance of the intron-retaining transcripts of the nxf1 genes.
Databáze:	OpenAIRE
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