Replacement of the phosphodiester linkage in oligonucleotides by an acetylenic bond: Comparison between carbon-, sulfur-, and oxygen-containing analogs

Autor:	Chantal Jouanno, Sebastian Wendeborn, Romain M. Wolf, Alain De Mesmaeker
Rok vydání:	1996
Předmět:	chemistry Oligonucleotide Stereochemistry Organic Chemistry Drug Discovery Phosphodiester bond chemistry.chemical_element RNA Biochemistry Carbon Oxygen Sulfur
Zdroj:	Tetrahedron Letters. 37:5511-5514
ISSN:	0040-4039
DOI:	10.1016/0040-4039(96)01164-1
Popis:	Four acetylene-containing dimers were synthesized and incorporated into oligonucleotides. The hybridization properties of the modified oligonucleotides to RNA complements and their conformational analysis are reported.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fb933012a2cd38ab24b9325e5892bd9f https://doi.org/10.1016/0040-4039(96)01164-1 Zobrazit plný text záznamu Full Text from ScienceDirect