Autoplex versus proplex: a controlled, double-blind study of effectiveness in acute hemarthroses in hemophiliacs with inhibitors to factor VIII
| Autor: | JM Lusher, PM Blatt, JA Penner, LM Aledort, PH Levine, GC White, AI Warrier, DA Whitehurst |
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| Rok vydání: | 1983 |
| Předmět: | |
| Zdroj: | Blood. 62:1135-1138 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v62.5.1135.bloodjournal6251135 |
| Popis: | In view of uncontrolled observations and anecdotal reports suggesting that the activated PCC, Autoplex, was much more effective than standard (non-activated) PCC in controlling bleeding in hemophiliacs with inhibitors, a controlled double-blind study was designed to compare the effectiveness of Autoplex and Proplex. Acute hemarthrosis was chosen for study as this common but non-life-threatening lesion lends itself well to controlled study. A single dose of “unknown” product (Autoplex 75 FECU/kg; Autoplex 50 FECU/kg; or Proplex 75 FIX U/kg) was given, and effectiveness was judged at 6 hr. By all criteria of efficacy, there were no significant differences between the products. It is noteworthy that a single dose of PCC was judged effective in 50% of episodes, a figure that is consistent with other published clinical trials. In this model, no additional benefit was derived from using the activated PCC, Autoplex, in either dosage. |
| Databáze: | OpenAIRE |
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