Preliminary observation on the influence of tumor osseous metastasis on autologous peripheral blood stem cell collection

Autor: Hongmei Zhang, Rong Sheng, Xiaoming Si, Wenchao Liu, Yan Xue, Jie Cheng, Ying Huang
Rok vydání: 2007
Předmět:
Zdroj: Chinese Journal of Clinical Oncology. 4:126-128
ISSN: 1993-5145
1672-7118
DOI: 10.1007/s11805-007-0126-4
Popis: OBJECTIVE To examine the influence of tumor osseous metastasis on the patients undergoing autologous peripheral blood stem cell collection. METHODS A total of 36 patients with malignant diseases who received an autologous peripheral blood stem cell transplantation, during a period from April 2004 to June 2006, were chosen. The patients were divided into two groups, i.e. group A were patients with a complication of tumor osseous metastasis, and group B were without metastasis. Both groups were treated with Taxotere 120 mg/m2 plus granulocyte colony-stimulating factor (G-CSF) 5 μg/kg/d, for a mobilization regimen. A blood cell separator was used to col -lect the mononuclear cells. The proportion of harvested CD34+ cells in the peripheral blood and the collected mononuclear cells were detected by flow cytometry. The number of CD34+ cells was used to determine the difference in the nature of the collections between the two groups. RESULTS After mobilization in groups A and B, the number of the periph-eral blood mononuclear cells (PBMC) was 39.3 ± 14.7 ％ and 41.1 ± 12.4％ and the proportion of CD34 + cells was 0.16 ± 0.07% and 0.17 ± 0.10%, respectively. Following administration of the drugs, there was no significant difference between the number of harvested PBMC and CD34+ cells of the two groups, i.e., 3.47 ± 1.16 × 10 8/Kg and 2.52 ± 1.43 × 10 6/Kg in group A and4.02 ± 1.31 × 10 8/Kg and 2.73 ± 1.87 × 10 6/Kg in group B, respectively. CONCLUSION Osseous metastasis, as a single factor, may have no impact on mobilization and harvesting of hematopoietic stem cells and their engraftment after autotransplantation.
Databáze: OpenAIRE
Externí odkaz: