Iron-Catalyzed Diborylation of Unactivated Aliphatic gem-Dihalogenoalkenes: Synthesis of 1,2-Bis(boryl)alkanes
Autor: | Xiao-Ming Zhang, Shangsheng Zhou, Zhengli Liu, Yu Pu, Zhang Feng, Jiang Zhu |
---|---|
Rok vydání: | 2021 |
Předmět: | |
Zdroj: | Organic Letters. 23:5565-5570 |
ISSN: | 1523-7052 1523-7060 |
Popis: | Herein, we report the first example of iron-catalyzed defluoroborylation of unactivated gem-difluoroalkenes, gem-dichloroalkenes, and gem-dibromoalkenes, providing the 1,2-bis(boryl)alkanes in moderate to good yield. This transformation has high regioselectivity, wide substrate scope, and excellent functional group compatibility. Preliminary mechanistic studies indicate that double β-F elimination is involved in the catalytic cycle, and the 1,1-diborylated alkenes might be intermediates in this iron-catalyzed 1,2-diborylation reaction. |
Databáze: | OpenAIRE |
Externí odkaz: |