Iron-Catalyzed Diborylation of Unactivated Aliphatic gem-Dihalogenoalkenes: Synthesis of 1,2-Bis(boryl)alkanes

Autor:	Xiao-Ming Zhang, Shangsheng Zhou, Zhengli Liu, Yu Pu, Zhang Feng, Jiang Zhu
Rok vydání:	2021
Předmět:	chemistry.chemical_compound chemistry Catalytic cycle Iron catalyzed Yield (chemistry) Organic Chemistry Functional group Organic chemistry Regioselectivity Substrate (chemistry) Physical and Theoretical Chemistry Biochemistry
Zdroj:	Organic Letters. 23:5565-5570
ISSN:	1523-7052 1523-7060
Popis:	Herein, we report the first example of iron-catalyzed defluoroborylation of unactivated gem-difluoroalkenes, gem-dichloroalkenes, and gem-dibromoalkenes, providing the 1,2-bis(boryl)alkanes in moderate to good yield. This transformation has high regioselectivity, wide substrate scope, and excellent functional group compatibility. Preliminary mechanistic studies indicate that double β-F elimination is involved in the catalytic cycle, and the 1,1-diborylated alkenes might be intermediates in this iron-catalyzed 1,2-diborylation reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fb600fea82e88dbdb1b53572dfd5ec06 https://doi.org/10.1021/acs.orglett.1c01967 Zobrazit plný text záznamu