| Autor: |
Qaiser Akram, Muhammad Umar Farid, Beenish Zahid, Muhammad Ahsan Naeem, Zeeshan Muhammad Iqbal, Shahid Hussain Farooqi, Asif Idrees, Qurban Ali, Muhammad Sulman Ali Taseer, Hafiz Muhammad Rizwan |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmaceutical Research International. :466-471 |
| ISSN: |
2456-9119 |
| Popis: |
Antibody response of buffalo calves to different levels of Foot and Mouth Disease (FMD) virus immunogen was investigated. Vaccine containing 106.2 units of immunogen/TCID50 of FMD virus (O, A and Asia-1) serotypes induced log2 (1.3± 0.4) units of anti-FMD O Complement Fixing Geometric Mean antibody (FMD O CFT-CGM) titer, log2 (1.4±0.3) units of anti-FMD A CFT-CGM titer and log2 (2.0±0.7) units of anti-FMD Asia-1 CFT-CGM titer. The vaccine containing 2x106.2 units of immunogen of each of the virus serotypes induced log2 (2.2±0.2) units of anti- FMD O CFT-CGM titer, log2 (2.1±0.25) units of anti- FMD A CFT-CGM titer and log2 (3.4±0.8) units of anti-FMD Asia-1 CFT-CGM titer. The vaccine containing 3x106.2 units of TCID50 of each of the virus serotypes induced log2 (5.3 ± 2.0) units of anti-FMD O CFT-CGM titer, log2 (4.6±1.9) units of anti-FMD A CFT-CGM titer and log2 (5.0±2.2) units of anti- FMD Asia-1 CFT-CGM titer. Moreover, buffalo calves (n=3) which were primed and boosted with 60 days interval using vaccine containing 2x106.2 units of immunogen of each of the virus serotype, showed log25.0 and log26.3 units of anti FMD O CFT-GMT antibody titer, log24.6 and log26.0 units of anti FMD A CFT GMT antibody titer, log25.6 and log26.0 units of anti FMD Asia-1 CFT GMT antibody titer, on 30 and 120 days post boosting. Antibody response of buffalo calves was directly proportional to amount of FMD virus immunogen serotypes in the vaccine. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
