Relationships between Alanine Aminotransferase Levels, Abnormal Liver Echogenicity, and Metabolic Syndrome
| Autor: | Yen-Lin Chang, Chuan-Chieh Liu, Chun Hsien Hsu, Hsiao-Shuang Chen, Jen-Yu Wang, Yen-Lin Chen, Dee Pei, Chun Pei |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Cross-sectional study business.industry Incidence (epidemiology) Public Health Environmental and Occupational Health Echogenicity Retrospective cohort study Odds ratio medicine.disease Logistic regression Group A Gastroenterology Endocrinology Internal medicine medicine Metabolic syndrome Family Practice business |
| Zdroj: | The Journal of the American Board of Family Medicine. 24:407-414 |
| ISSN: | 1558-7118 1557-2625 |
| DOI: | 10.3122/jabfm.2011.04.100267 |
| Popis: | Background: Elevated alanine aminotransferase (e-ALT) and abnormal liver echogenicity (ab-echo), as determined by sonography, have been linked to metabolic syndrome (MetS). However, which of these is more closely related to MetS, especially among older men, remains unknown. Methods: Data from 3065 men aged 65 years or older who were undergoing a routine health examination and who were not taking any medications for MetS were analyzed retrospectively. The patients were divided into 4 groups: group N (n = 1228; patients have normal ALT and liver echogenicity); group A (n = 110; patients have e-ALT but normal liver echogenicity); group E (n = 1381; patients have ab-echo but normal ALT); group AE (n = 346; patients have both e-ALT and ab-echo). Results: Among the 3065 subjects, 714 participants were found to have MetS (23.3%). It is not surprising that MetS components were highest in group AE. More interestingly, compared with group A, group E had higher levels of MetS components (except that high-density lipoprotein cholesterol levels were lower). Similar findings were confirmed by logistic regression. Group E had a significantly higher odds ratio of having MetS than group A (2.73; 95% CI, 1.565–4.763). Conclusions: Our data confirm that both e-ALT and ab-echo are related to a higher incidence of MetS among Taiwanese older men. Of these 2 abnormalities, ab-echo seems to be more closely related to MetS. Further studies are needed to elucidate the complex relationships between these factors in other age and ethnic groups. |
| Databáze: | OpenAIRE |
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