Genotoxic properties of haloacetonitriles: Drinking water by-products of chlorine disinfection*1

Autor:	Joan K. Mattox, Edith L.C. Lin, D. L. Haas, K. M. Schenck, F. B. Daniel, Michael A. Pereira
Rok vydání:	1986
Předmět:	Bromine Chemistry chemistry.chemical_element Halogenation Toxicology chemistry.chemical_compound Nucleophile Covalent bond Environmental chemistry Pyridine Chlorine Organic chemistry Water pollution Carcinogen
Zdroj:	Fundamental and Applied Toxicology. 6:447-453
ISSN:	0272-0590
DOI:	10.1016/0272-0590(86)90218-6
Popis:	Chlorinated and brominated haloacetonitriles (HAN), known drinking water contaminants which form during chlorine disinfection, were investigated for genotoxic activity. The HAN produced DNA strand breaks in cultured human lymphoblastic (CCRF-CEM) cells, bound to the nucleophilic trapping agent 4-(p-nitrobenzyl)pyridine and formed a covalent bond to polyadenylic acid in a cell-free reaction system. Thus, we have demonstrated that these chemicals are genotoxic, which would indicate a potential for carcinogenic activity and for human health hazard.
Databáze:	OpenAIRE
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