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Drugs, chemicals, or plants can produce toxic effects on the whole animal as well as on the heart. Twenty chemicals and drugs were selected to show that there is no specific uniform toxicity effect across animal species. It is noted from the graphics displayed FIGURE 13.1 Toxic effects of selected organic chemicals , FIGURE 13.2 Toxic effects of selected drugs and FIGURE 13.3 Toxic effects of selected chemicals that there does not appear to be one species that is more or less sensitive to drugs or chemicals overall. It is recognized that certain chemicals are much more or FIGURE 13.1 Toxic effects of selected organic chemicals. Figure options FIGURE 13.2 Toxic effects of selected drugs. Figure options FIGURE 13.3 Toxic effects of selected chemicals. Figure options Download full-size image Download as PowerPoint slide less toxic than others because of their inherent mechanism. Botulinum toxin, for example, is toxic because it interacts with specific protein receptors in the body. Some of the drugs that are recognized as antidotes for toxic chemicals are in and of themselves toxic. For example, physostigmine (Figure 13.2) (which protects against anticholinesterase agents) and Valium® (Figure 13.3) (both of which has anti-arrhythmic and anti-convulsant properties versus a variety of agents) also display a varied toxicity pattern across species. |
