Anaerobic exercise causes transient changes in leukocyte subsets and IL-2R expression
| Autor: | Timothy K. Roberts, A. B. Gray, Maurice J. Weidemann, Smart Yc, Richard D. Telford |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Interleukin 2
Cellular immunity medicine.medical_specialty biology business.industry CD3 medicine.medical_treatment Physical Therapy Sports Therapy and Rehabilitation Physical exercise Cytokine Endocrinology Internal medicine biology.protein medicine Orthopedics and Sports Medicine IL-2 receptor business Anaerobic exercise medicine.drug Whole blood |
| Zdroj: | Medicine & Science in Sports & Exercise. 24:1332 |
| ISSN: | 0195-9131 |
| DOI: | 10.1249/00005768-199212000-00005 |
| Popis: | There is evidence that the stress of intense athletic competition and training depresses cellular immunity and predisposes athletes to increased infection. This paper reports changes in circulating leukocyte subsets of trained (group I: VO2max = 67.2 +/- 5.4 ml.kg-1min-1; age = 22.0 +/- 6.2 yr) and untrained (group II: VO2max = 55.0 +/- 4.9 ml.kg-1min-1; age = 21.4 +/- 2.0 yr) males following 1 min of bicycle ergometry at maximum effort. Significant post-exercise increases in concentrations of total leukocytes, monocytes, lymphocytes, CD3+, CD4+, CD8+ lymphocytes were observed in both groups (all P 0.05). Despite groups I and II not differing in either peak power or total work performed during the exercise test (P > 0.05), group II had a significantly greater concentration and percentage of CD8+ lymphocytes immediately after exercise (P < 0.01). All of the early changes were transient, with normalization occurring within 1 h. Only trained subjects showed a significant decrease in the percentage of CD25+ lymphocytes following PHA stimulation of whole blood obtained 6 h post-exercise. Alterations in leukocyte subpopulations found in response to predominantly anaerobic exercise appear to be associated with a significant, but possibly transient, alteration in the mitogenic responsiveness of lymphocytes that is restricted to aerobically trained subjects. |
| Databáze: | OpenAIRE |
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