Nitration Chemistry in Continuous Flow using Fuming Nitric Acid in a Commercially Available Flow Reactor

Autor:	Hansjörg Lehmann, Cara E. Brocklehurst, Luigi La Vecchia
Rok vydání:	2011
Předmět:	Exothermic reaction Explosive material business.industry Organic Chemistry Flow chemistry Acetic acid chemistry.chemical_compound Flow (mathematics) chemistry Nitric acid Nitration SCALE-UP Organic chemistry Physical and Theoretical Chemistry Process engineering business
Zdroj:	Organic Process Research & Development. 15:1447-1453
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op200055r
Popis:	The paper will describe the use of flow chemistry for scaling up exothermic or hazardous nitration reactions. Such reactions often cause time delays to the delivery of larger batches of intermediates or final compounds for medicinal chemistry projects, because considerable time is required for safety evaluation and, if necessary, modification of the procedure so that it can be scaled-up and run in a safe manner. A commercially available continuous flow reactor was used in the scale up of three challenging nitrations including a reaction involving a potentially explosive mixture of acetic acid and fuming nitric acid, with a productivity of 97 g/h.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fb4a00f598498fb534b50a759f1fc9f4 https://doi.org/10.1021/op200055r Zobrazit plný text záznamu