Association of Single-Nucleotide Polymorphisms of Gene XPC with Susceptibility to Basal Cell Carcinoma in Brazilian Population
| Autor: | Mayara Dos Santos Maia, Otávio Sérgio Lopes, Poliane Da Silva Calixto, Sylvia Satomi Takeno Herrero, Augusto Monteiro de Souza, Carlos Alberto Longui, Ivan Rodrigues de Carvalho Filho, Leonardo Ferreira Soares, Plínio Delatorre, Renally Barbosa da Silva, Danielle Calcagno, Rommel Rodriguez Burbano, Eleonidas Moura Lima |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | SKIN The Journal of Cutaneous Medicine. 7:570-580 |
| ISSN: | 2574-1624 7457-6917 |
| DOI: | 10.25251/skin.7.1.2 |
| Popis: | Background: Basal cell carcinoma (BCC) is the common neoplasm in humans and its main etiological factor is exposure to solar radiation. Mutations in repair genes can lead to tumor progression and loss of cell integrity leading to the onset of cancer. Nucleotide excision repair (NER) is an important mechanism primarily used to repair injuries caused by UV. Objective: To evaluate and describe for the first time the single nucleotide polymorphisms rs745769173, rs761106780 and rs535425175 and risk of developing BCC. Methods: The present study analyzed 100 samples of paraffin-embedded tissue from patients with histopathological diagnosis of BCC and 100 control samples. The results were obtained by genotyping method, Dideoxy Unique Allele Specific – PCR (DSASP) and molecular modeling. Results: The SNP rs535425175 of the XPC gene showed a significant association with the BCC in the analyzed samples (P |
| Databáze: | OpenAIRE |
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