Idiopathic hemochromatosis: serum ferritin concentrations during therapy by phlebotomy

Autor:	J H Saiki, P J Garry
Rok vydání:	1982
Předmět:	Pathology medicine.medical_specialty biology Chemistry Iron absorption Biochemistry (medical) Clinical Biochemistry Total body Phlebotomy Ferritin Endocrinology Idiopathic hemochromatosis Internal medicine Iron content medicine biology.protein Hemoglobin Serum ferritin
Zdroj:	Clinical Chemistry. 28:1806-1808
ISSN:	1530-8561 0009-9147
DOI:	10.1093/clinchem/28.8.1806
Popis:	We report the case of a 54-year-old man who presented with symptoms of idiopathic hemochromatosis, an inherited disorder involving regulation of iron absorption. These symptoms usually do not appear until total body iron content reaches 15 g, about threefold normal. Therapy involves mobilization and removal of excess stored iron through weekly or twice-weekly phlebotomies of 500 mL, until the hemoglobin concentration becomes less than 110 g/L and remains there for several weeks, or until serum ferritin concentrations indicate that almost all the stored iron has been removed (ferritin less than 12 micrograms/L). Here, concentrations of ferritin in serum were used as an index to iron overload and removal of stored iron. We report changes in hemoglobin, serum ferritin, iron, and total iron-binding capacity during the course of removing by phlebotomy more than 20 g of iron from a patient with idiopathic hemochromatosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fb467c8403bfd733214a5f8ec0b7cc49 https://doi.org/10.1093/clinchem/28.8.1806 Zobrazit plný text záznamu