Solid-phase versus solution synthesis of asymmetrically disubstituted furazano[3,4-b]pyrazines

Autor:	Sophie Huss, Araceli Mallo, Alfredo Paio, Jose M. Bueno, Paola Zarantonello, Silvestre Garcı́a-Ochoa, Fabrizio Micheli, Elisa Piga, Esther Fernández
Rok vydání:	2002
Předmět:	Pyrazine Chemistry Organic Chemistry Chlorine atom Solution chemistry Solution synthesis Biochemistry Combinatorial chemistry chemistry.chemical_compound Nucleophile Phase (matter) Drug Discovery Organic chemistry Selectivity
Zdroj:	Tetrahedron Letters. 43:4741-4745
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(02)00913-9
Popis:	Herein we describe a straightforward solid-phase synthesis directed towards the preparation of families of asymmetrically disubstituted furazano[3,4-b]pyrazines by stepwise displacement of the two chlorine atoms in 5,6-dichlorofurazano[3,4-b]pyrazine by nucleophiles. This synthesis has avoided selectivity problems found in solution chemistry.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fb427161a868d885141adabef20b935f https://doi.org/10.1016/s0040-4039(02)00913-9 Zobrazit plný text záznamu Full Text from ScienceDirect