Solid-phase versus solution synthesis of asymmetrically disubstituted furazano[3,4-b]pyrazines
Autor: | Sophie Huss, Araceli Mallo, Alfredo Paio, Jose M. Bueno, Paola Zarantonello, Silvestre Garcı́a-Ochoa, Fabrizio Micheli, Elisa Piga, Esther Fernández |
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Rok vydání: | 2002 |
Předmět: | |
Zdroj: | Tetrahedron Letters. 43:4741-4745 |
ISSN: | 0040-4039 |
Popis: | Herein we describe a straightforward solid-phase synthesis directed towards the preparation of families of asymmetrically disubstituted furazano[3,4-b]pyrazines by stepwise displacement of the two chlorine atoms in 5,6-dichlorofurazano[3,4-b]pyrazine by nucleophiles. This synthesis has avoided selectivity problems found in solution chemistry. |
Databáze: | OpenAIRE |
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