ChemInform Abstract: Synthesis and Antimicrobial Activity of 7-(2-Substituted phenylthiazolidinyl)-benzopyran-2-one Derivatives

Autor:	Pradeepkumar Ronad, Malleshappa N. Noolvi, Satyanarayana Dharbhamulla, Sheetal Sapkal, Veeresh Maddi
Rok vydání:	2010
Předmět:	medicine.drug_class Antibiotics General Medicine Carbon-13 NMR Griseofulvin Antimicrobial Benzopyran Ciprofloxacin chemistry.chemical_compound chemistry Proton NMR medicine Organic chemistry Thioglycolic acid medicine.drug
Zdroj:	ChemInform. 41
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.201019126
Popis:	A series of 7-(2-substituted phenylthiazolidinyl)-benzopyran-2-one derivatives have been synthesized by reaction of 7-amino-4-methyl-benzopyran-2-one (1) with an appropriate substituted aldehydes to obtain various Schiff bases (3a-k) which on treatment with thioglycolic acid afforded the title compounds (4a-k). Purity of the compounds has been confirmed by TLC. Structure of these compounds were established on the bases IR, 1H NMR, 13C NMR and Mass spectral data. Schiff bases and title compounds were evaluated for antibacterial and antifungal activities against various bacterial and fungal strains. The results showed that compounds 3d, 3f, 4d, 4f and 4i (100 microg/ml) exhibited good antibacterial and antifungal activity as that of standard antibiotics Ciprofloxacin and Griseofulvin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fb3d80f04f440dbc7f9b676f5ebc8fb9 https://doi.org/10.1002/chin.201019126 Zobrazit plný text záznamu Plný text