Eccentric contractions induce rapid isometric torque drop in dystrophin-deficient dogs
| Autor: | Chad D. Markert, Robert W. Grange, Christopher J. Tegeler, Doug Case, Martin K. Childers, Daniel J. Bogan, Joe N. Kornegay |
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| Rok vydání: | 2010 |
| Předmět: |
Golden retriever muscular dystrophy
medicine.medical_specialty genetic structures biology Physiology business.industry Drop (liquid) Duchenne muscular dystrophy Isometric torque Eccentric contractions Isometric exercise Anatomy medicine.disease stomatognathic diseases Cellular and Molecular Neuroscience Physiology (medical) Internal medicine Cardiology biology.protein Medicine Neurology (clinical) Muscular dystrophy business Dystrophin |
| Zdroj: | Muscle & Nerve. 42:130-132 |
| ISSN: | 0148-639X |
| Popis: | We tested the hypothesis that eccentric contractions (ECCs) rapidly induce greater-than-normal isometric torque drop in dystrophin-deficient golden retriever muscular dystrophy (GRMD) muscles. ECCs were imposed by forcibly stretching activated muscles. The results indicate that isometric torque drop was greater in GRMD versus controls (P < 0.0001). Our findings support the hypothesis that ECCs induce greater-than-normal isometric torque drop in GRMD muscles. The magnitude of ECC-induced isometric torque loss may be an ideal clinical endpoint in the GRMD model. |
| Databáze: | OpenAIRE |
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