| Autor: |
José Luis Salvador Sanchís, Jesús Nomdedeu Guinot, Isabel Salinas, Vicente Ángel Yepes, Manuel Alós Almiñana, José Manuel Ventura Cerdá |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Medicina Clínica. 129:121-126 |
| ISSN: |
0025-7753 |
| Popis: |
BACKGROUND AND OBJECTIVE: To prove that a single-preoperative dose (SD) of metronidazole plus gentamicin guarantees the same clinical effectiveness than the same dose administered in a multiple-perioperative schedule (MD), with a reduction of the direct costs. PATIENTS AND METHOD: A retrospective cohort study with patients undergoing elective colorectal surgery between 1995 and 2003 was designed. Patients in the cohort of cases received a SD of metronidazole 1500 mg plus gentamicin 240 mg between 1999 and 2003. Patients included in the cohort of controls received the same dose of antibiotics in a MD schedule between 1995 and 1997. Clinical effectiveness was evaluated as length of stay, mortality and rate of surgical-related infections. Economic analysis was performed using direct costs of therapy exclusively. RESULTS: 414 patients were included in the cohort of MD and 978 were included in the cohort of SD. Total length of stay (standard deviation) was 15.1 (16.2 days), with a significant reduction in the SD cohort versus the MD cohort: 14.0 (15.4) days versus 17.5 (17.8) days (p < 0.001). No differences in mortality (overall rate 3.2%) or surgical infection rate (overall rate 8.6%) between cohorts were found. SD schedule produces a 35% cost-reduction per procedure. CONCLUSIONS: Attending the clinical effectiveness, no differences between SD and MD cohorts were found. Therefore, according to logistics advantages and costs reduction, the SD of antibiotic is considered the most efficient option. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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