| Autor: |
Patrycja Daca-Roszak, Roman Jaksik, Julia Paczkowska, Michal Witt, Ewa Zietkiewicz |
| Rok vydání: |
2020 |
| DOI: |
10.21203/rs.3.rs-20643/v1 |
| Popis: |
Background Epigenetics is one of the factors shaping natural variability observed among human populations. A small proportion of heritable inter-population differences are observed in the context of both the genome-wide methylation level and the methylation status of individual CpG sites. It has been demonstrated that a limited number of carefully selected differentially methylated sites may allow discrimination between main human populations. However, most of the few published results have been performed exclusively on B-lymphocyte cell lines. Results The goal of our study was to identify a set of CpG sites sufficient to discriminate between Caucasian and Chinese populations based on the difference in the DNA methylation profile not only in cell lines but also in primary cell samples. The preliminary selection of CpG sites differentially methylated in these two populations (pop-diff-met CpGs) was based on the analysis of two groups of commercially available ethnically-specific B-lymphocyte cell lines, performed using Illumina Infinium Human Methylation 450 BeadChip Array. A subset of ten pop-diff-met CpGs characterized by the best differentiating criteria (|Mdiff|>1, q |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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