Effect of tissue-type plasminogen activator from calf kidney cell culture on hemostasis and fibrinolysis in experimental nephritis
| Autor: | A. V. Lyaginskii, G. A. Afanasenko, L. V. Podorolskaya, B. B. Egorov, T. N. Serebryakova, G. V. Andreenko |
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| Rok vydání: | 1988 |
| Předmět: |
Urokinase
Pathology medicine.medical_specialty biology Plasmin business.industry medicine.medical_treatment Glomerulonephritis General Medicine medicine.disease General Biochemistry Genetics and Molecular Biology Fibrin Fibrinolysis medicine biology.protein business Plasminogen activator Nephritis Fibrinolytic agent medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 106:1410-1412 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00837749 |
| Popis: | A secondary stage in the pathogenesis of glomerulonephritis, accompanied by a nephrotic syndrome, is fibrin deposition in the basement membranes of the renal glomeruli, making the use of anticoagulant and fibrinolytic agents essential in the treatment of this disease. Urokinase, which activates plasminogen circulating in the blood stream is used most frequently in clinical practice. However, the active plasmin formed may itself be an additional factor causing destruction of the already damaged vascular bed of the renal glomeruli, and thus aggravating the pathology. Cases of temporary worsening of the disease after administration of urokinase in nephritis have been described in the literature [7, 8]. It can be postulated that plasminogen activators of tissue type (TPA), giving rise to local lysis of fibrin without generalized activation of plasminogen, will be more appropriate agents for the removal of fibrin deposits in the capillaries of the kidneys and for the treatment of nephritis. |
| Databáze: | OpenAIRE |
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