Effect of commercial Makgeolli on tumor growth in tumor xenograft mice
| Autor: | Sung-Kwan Yum, Jin-Taek Hwang, Jae Ho Kim, Ki-Seung Seong, Eun-Ju Shin |
|---|---|
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Korean Journal of Food Preservation. 23:104-109 |
| ISSN: | 2287-7428 1738-7248 |
| DOI: | 10.11002/kjfp.2016.23.1.104 |
| Popis: | The purpose of this study was to evaluate the inhibitory effect of commercial Makgeolli on tumor growth in human gastric adenocarcinoma cells (AGS) in a xenograft cancer model, transplanted with AGS cells. Commercial Makgeolli was first dealcoholized by evaporation and used as the test sample. We detected a significant increase in the volume and weight of tumor in nude mice (induction) that were transplanted with AGS cells. Administration of 100 mg/kg·day group (ML), and 500 mg/kg·day group (MH) dealcoholized commercial Makgeolli significantly decreased tumor growth. In this study, 5-FU 18 mg/kg·day was used as a positive control for tumor growth inhibition. Additionally, determination of the body weight of both the groups revealed no side effects after the administration of dealcoholized commercial Makgeolli. Using the cell culture system, we also evaluated the effect of dealcoholized commercial Makgeolli on caspase-3/7 activity in the AGS cells. Treatment with dealcoholized commercial Makgeolli increased the activation of caspase-3/7 and the apoptotic markers in AGS cells in a dose-dependent manner. Therefore, dealcoholized commercial Makgeolli can be used for cancer prevention. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|