Neuroendocrine carcinoma of the uterine cervix: 15-year experience from a tertiary care centre in Southern India
| Autor: | Arvind Sathyamurthy, Kaalindi Singh, Anitha Thomas, Thomas Samuel Ram, Sobin V. Jacob, Jeba Karunya Ramireddy |
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| Rok vydání: | 2020 |
| Předmět: |
Cervical cancer
0303 health sciences medicine.medical_specialty Chemotherapy Neuroendocrine carcinoma of the cervix business.industry medicine.medical_treatment Brachytherapy medicine.disease Surgery Radiation therapy 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis medicine Radiology Nuclear Medicine and imaging Stage (cooking) business Cervix Pathological 030304 developmental biology |
| Zdroj: | Journal of Radiotherapy in Practice. 20:164-167 |
| ISSN: | 1467-1131 1460-3969 |
| DOI: | 10.1017/s1460396920000096 |
| Popis: | Aim:To analyse the presentation, treatment strategies and outcomes of neuroendocrine carcinoma of cervix treated with multi-modality approach at our institute.Materials and methods:The data of patients diagnosed to have cervical cancer between October 2004 and November 2018 were retrieved, and 14 patients of neuroendocrine carcinoma cervix who received treatment in our institution were identified. The patients were analysed based on demographic characteristics, disease stage, pathological characteristics, treatment and follow-up. The median overall survival and disease-free survival were calculated.Results:Median follow-up period was 8 months (range 1–52 months). Six patients died within 4 months of completion of treatment due to disease progression. Median overall survival was 12 months and median disease-free interval was 5·5 months. Four of the patients who underwent combined modality treatment consisting of neoadjuvant chemotherapy, concurrent chemoradiation therapy and brachytherapy are still on regular follow-up and are disease-free.Conclusion:Neuroendocrine carcinoma of the cervix is a rare but aggressive histological subtype. Combined modality approach with judicious use of systemic chemotherapy along with surgery and radiation therapy is essential for optimal outcomes. |
| Databáze: | OpenAIRE |
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