Efficacy of dual antiplatelet therapy combined with Naoxintong Capsules (脑心通胶囊) following coronary microembolization induced by homologous microthrombi in rats
| Autor: | Wen-juan Zhong, Xiaoying Wu, Ming-wei Huang, Huan Wang, Hui Chen |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Aspirin
medicine.medical_specialty medicine.diagnostic_test Traditional medicine Combination therapy business.industry education Capsule General Medicine Clopidogrel Gastroenterology Pharmacotherapy Text mining Complementary and alternative medicine Clotting time Bleeding time Internal medicine medicine Pharmacology (medical) business medicine.drug |
| Zdroj: | Chinese Journal of Integrative Medicine. 17:917-924 |
| ISSN: | 1993-0402 1672-0415 |
| DOI: | 10.1007/s11655-011-0935-4 |
| Popis: | To evaluate the effificacy of dual antiplatelet therapy combined with Naoxintong Capsule (脑心通胶囊, NXTC) in a rat model of coronary microembolization (CME). A total of 95 rats were randomly divided into 6 groups: control, sham-operation, CME model, NXTC, dual antiplatelet (clopidogrel and aspirin) intervention (DA), and NXTC combined with DA (NDA) groups. The complete data in 69 rats were obtained. The number of CME, myocardial apoptosis rate, bleeding time, clotting time, and adensosine diphosphate (ADP)-induced platelet aggregation were assessed. Compared with the CME group, the number of CME and myocardial apoptosis rates were signifificantly decreased in the NXTC, DA, and NDA groups (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink