A Practical Synthesis of Highly Hindered Biphenyl-2-carboxylates via Nucleophilic Aromatic Substitution of tert-Butyl 2-Methoxybenzoates with Aryl Grignard Reagent

Autor:	Yoshikazu Haraguchi, and Takuya Furuta, Shinji Aki, Takafumi Fujioka, Masashi Ishigami, Hiroshi Sakikawa, Jun-ichi Minamikawa
Rok vydání:	2001
Předmět:	Biphenyl Tert butyl Methoxybenzoates Chemistry Aryl Organic Chemistry Grignard reagent Medicinal chemistry stomatognathic diseases chemistry.chemical_compound nervous system Fluorenone Nucleophilic aromatic substitution Physical and Theoretical Chemistry Derivative (chemistry)
Zdroj:	Organic Process Research & Development. 5:535-538
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op0001279
Popis:	The fluorenone derivative (OPC-34165) has potent repairing and protecting activities for peripheral and central nervous system degeneration. A synthesis of the biphenyl-2-carboxylic acid derivative, which is the key intermediate of OPC-34165, is described employing the SNAr reaction of tert-butyl 2-methoxybenzoate with aryl Grignard reagent in refluxing THF−toluene.
Databáze:	OpenAIRE
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