Relating contact surface hydrophobicity to molecular events influencing biological adhesion
| Autor: | Viwat Krisdhasima, Joseph McGuire |
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| Rok vydání: | 1993 |
| Předmět: | |
| Zdroj: | Journal of Adhesion Science and Technology. 7:195-204 |
| ISSN: | 1568-5616 0169-4243 |
| DOI: | 10.1163/156856193x00655 |
| Popis: | Quantification of the effects of selected contact surface properties on kinetic rate constants that describe protein arrival and unfolding at solid-liquid interfaces should aid our understanding of the nature of biological adhesion. We observed that the product of rate constants defining protein arrival and conversion to an irreversibly adsorbed state increased with increasing surface hydrophobicity, while the rate constant defining desorption of protein from a reversibly adsorbed state apparently decreased. However, the hydrophobicity of a contact material, as measured by the non-dispersive component of the work required to remove water from its surface, did not correlate with protein surface activity over the entire range of hydrophobicity tested. Our studies with silicon suggested that limited silanization with dichlorodimethylsilane yielded an increased hydrophobicity, but no observable increase in the entropic driving force for adsorption, i.e. no adsorption-enhancing hydrophobic effect. Apparently, ... |
| Databáze: | OpenAIRE |
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