Tetrazoles. 24. Preparation of 1,4-dimethyl- and 2,4-dimethyl-5-aryl-tetrazolium salts

Autor:	M. V. Chekushina, G. B. Erusalimskii, G. I. Koldobskii, I. Yu. Shirobokov, Vladimir A. Ostrovskii
Rok vydání:	1988
Předmět:	chemistry.chemical_compound Dimethyl sulfate chemistry Aryl Organic Chemistry Organic chemistry Reactivity (chemistry) Methylation Formazan Alkylation Medicinal chemistry Ion
Zdroj:	Chemistry of Heterocyclic Compounds. 24:413-417
ISSN:	1573-8353 0009-3122
DOI:	10.1007/bf00478861
Popis:	Alkylation of 1-methyl-5-aryltetrazoles with dimethyl sulfate leads to the formation of 1,4-dimethyl-5-aryltetrazolium ion salts. Alkylation of isomeric 2-methyl-5-aryltetrazoles also apparently takes place at the N(4) atom. 1-Methyl-5-aryltetrazoles display greater reactivity with respect to methylation than the isomeric 2-methyl-5-aryltetrazoles. 1,4-Dimethyl-5-aryltetrazolium methylsulfate salts isomerize upon heating to give the more stable 2,4-dimethyl-5-aryltetrazolium ion salts.
Databáze:	OpenAIRE
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