| Autor: |
D.A. Hollingsbee, L.A. Chambers, Michael Walker, Jonathan Hadgraft |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
International Journal of Pharmaceutics. 70:167-172 |
| ISSN: |
0378-5173 |
| DOI: |
10.1016/0378-5173(91)90177-p |
| Popis: |
In vitro comparisons of the delivery of the topical corticosteroid halcinonide from a 0.1% cream (Halcinonide Cream USP) have been investigated. Finite dose diffusion experiments through human epidermal membranes were carried out to evaluate the effect of application quantity on the rate of epidermal permeation. At ‘clinically’ low levels of application (i.e. less than 5 mg/cm 2 of cream) a dose-dependent low rate of permeation was observed. With applications of 5 mg/cm 2 and above the rate of permeation appeared constant although the total amount penetrating the membrane was dependent on the dose. These results produced from carefully controlled experiments using the same skin source emphasise the need for accurate in vitro experimentation to mimic in vivo dose application. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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