Serum 25(OH) Vitamin D Concentration Changes After Roux-en-Y Gastric Bypass Surgery

Autor: Charlene Compher, Sayeed Ikramuddin, Carrie P. Earthman, William Thomas, Lauren M. Beckman, Shalamar D. Sibley, Juan Muniz, Todd A. Kellogg, Ronald L. Horst
Rok vydání: 2013
Předmět:
Zdroj: Obesity. 21:E599-E606
ISSN: 1930-7381
DOI: 10.1002/oby.20464
Popis: Objective To describe serum 25(OH)D changes after Roux-en-Y gastric bypass (RYGB) and to determine if fat mass (FM) loss and vitamin D intake are associated with changes in serum levels. Design and Methods: The relationship between serum 25(OH)D and 1) FM, 2) weight, 3) % excess weight loss (EWL), and 4) BMI was investigated after controlling for potential confounders using a mixed effects linear model in 20 women before and up to 1-year post-RYGB. Subcutaneous (SAT) and visceral adipose tissue (VAT) vitamin D concentrations at time of RYGB were also evaluated. Results Weight and FM decreased 1-year after surgery by 45 ± 1 kg and 37 ± 1 kg, respectively while 25(OH)D increased by 10 ± 2 ng mL−1. Weight, FM, BMI, and %EWL changes were associated with 25(OH)D change. VAT had an average 21% more vitamin D per gram than SAT and concentrations were highly correlated. Conclusions Although weight loss may lead to increased serum 25(OH)D after RYGB, low levels remain a concern in some patients 1-year postsurgery. Additional research is needed to clarify the relationship between adipose storage of vitamin D and serum 25(OH)D in obesity, and how that relationship might change after surgery. This could lead to improved clinical management of vitamin D in this ever-growing clinical population.
Databáze: OpenAIRE
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