Copper-Catalyzed Intermolecular Thioamination of Maleimides with Thiols and Formamides: A One-Step Construction of 3-Amino-4-thiomaleimides Using Formamides as Nitrogen Sources
| Autor: | Zhen-Hua Yang, Jia-Nan Zhu, Ze-Hui Jin, Jian Zheng, Sheng-Yin Zhao |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
010405 organic chemistry
Fluoroboric acid Organic Chemistry Intermolecular force chemistry.chemical_element One-Step Bond formation 010402 general chemistry 01 natural sciences Combinatorial chemistry Nitrogen Catalysis 0104 chemical sciences chemistry.chemical_compound chemistry Copper catalyzed Formamides |
| Zdroj: | Synthesis. 50:4627-4636 |
| ISSN: | 1437-210X 0039-7881 |
| DOI: | 10.1055/s-0037-1610536 |
| Popis: | A highly efficient copper-catalyzed intermolecular C(sp2)–H thioamination of maleimides with thiols and formamides in the presence of fluoroboric acid is reported using various readily available formamides as nitrogen sources and solvents. A diverse range of 3-amino-4-thiomaleimides is obtained with good yields under mild conditions, involving C–N and C–S bond formation. This methodology enriches current C–N and C–S bond formation chemistry and features operational simplicity and excellent functional-group tolerance. |
| Databáze: | OpenAIRE |
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