Participation of the CD27 antigen in the regulation of IL-2-activated human natural killer cells

Autor:	K Sugita, M J Robertson, Y Torimoto, J Ritz, S F Schlossman, C Morimoto
Rok vydání:	1992
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 149:1199-1203
ISSN:	1550-6606 0022-1767
Popis:	The CD27 Ag is expressed by the majority of resting T lymphocytes and appears to play a crucial role in T cell activation. We found that some resting peripheral blood NK cells also express CD27. Furthermore, CD27 expression was up-regulated on NK cells stimulated by IL-2. The cytolytic activity of IL-2-activated, but not resting, NK cells was inhibited by an anti-CD27 mAb (anti-1A4). However, anti-1A4 did not affect conjugate formation between IL-2-activated NK cells and tumor cell targets. In contrast, anti-1A4 inhibited CD2-mediated calcium mobilization and the serine esterase activity of NK cell granules. These inhibitory effects could be mediated in part by increase in intracellular cAMP levels induced by anti-1A4. Our results suggest that the CD27 Ag plays an important role in the regulation of activated NK cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fae17e407c2adcdc3a32a10c076950bd https://doi.org/10.4049/jimmunol.149.4.1199 Zobrazit plný text záznamu