Frequency of Tumor Lysis Syndrome in Acute Leukemia
| Autor: | Shafaq Samad, Jahanzeb Khaliq, Tahir Shamsi, Mehwish Taj |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Acute leukemia medicine.diagnostic_test business.industry Common disease medicine.disease Gastroenterology Peripheral blood Tumor lysis syndrome Leukemia medicine.anatomical_structure hemic and lymphatic diseases Internal medicine Biopsy medicine Bone marrow Complication business |
| Zdroj: | National Journal of Health Sciences. 4:67-70 |
| ISSN: | 2519-7878 2519-7053 |
| DOI: | 10.21089/njhs.42.0067 |
| Popis: | Introduction: Acute leukemia is characterized by the presence of 20% or more blasts in peripheral blood and/or bone marrow biopsy. It includes both AML & Acute ALL. However the diagnosis of AML can also be made when the blast percentage in peripheral blood or bone marrow is < 20 % if there is an associated t (8;21), inv (16), or t (16;16) chromosomal abnormality or PML-RAR fusion gene [1-3]. Tumor lysis syndrome is the most common disease related emergency in patients with leukemia & requires immediate management. Objective: To ascertain the Frequency of TLS in Acute Leukemia. Study design: Cross sectional study.Setting: NIBD & BMT, Karachi. Duration of study: The duration of study was 6 months i.e. from May 2016 to November 2016.Results: 111 patients were enrolled in this study. 41 (36.9%) patients were female & 70 (63.1%) were male, with mean age of 42.8±15.5 years. 66 (59.4%) patients were found to have AML & ALL was seen in 45 (40.6%) patients. Tumor lysis in AML was seen in 21 patients (18.9%) of which 15 patients (13.5%) had LTLS & 06 patients (5.4%) had CTLS. Tumor lysis in ALL was seen in 23 patients (20.7%) of which 16 patients (14.4%) had LTLS & 07 patients (6.3%) had CTLS. Conclusion: TLS is a frequently common disease related complication in patients with acute leukemia. LTLS is found to be more common than CTLS both in AML & ALL. |
| Databáze: | OpenAIRE |
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