ASSOCIATION BETWEEN SINGLE POLYMORPHISM IN THE LOCUS RS17216473 OF THE GENE THAT ENCODES 5-LIPOXYGENASEACTIVATING PROTEIN AND RISK OF MYOCARDIAL INFARCTION
Autor: | Viktor E. Dosenko, Iryna G Strokina, L. M. Sokurenko, Drevyts'ka Ti, Oleksii Ur Pavlenko |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
education.field_of_study medicine.medical_specialty business.industry Population Infarction Single-nucleotide polymorphism General Medicine 030204 cardiovascular system & hematology medicine.disease Gastroenterology Minor allele frequency 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Polymorphism (computer science) Internal medicine Genotype medicine cardiovascular diseases Myocardial infarction Allele business education |
Zdroj: | Wiadomości Lekarskie. 73:2431-2437 |
ISSN: | 0043-5147 |
Popis: | Objective The aim: To study the association between A/A, G/A, A/A genotypes, alleles A, G of the SNP rs17216473 of the gene that encodes ALOX5AP and the risk of myocardial infarction within the Ukrainian population. Patients and methods Materials and methods: PCR in real time and the analysis to discriminate alleles were used. The statistical processing was carried out by χ2 criteria and by χ2 criteria with Yates correction. Results Results: For the first time the SNP rs17216473 of gene that encodes ALOX5AP has been established to be statistically significantly associated with the risk of myocardial infarction in Ukrainian population. The connection with genotype A/A was opposite to that with genotype G/G. That is, A/A contribution to myocardium infarction has been statistically significant whereas, G/G has been statistically significantly associated with the absence of myocardial infarction. G/A genotype has not been statistically significantly associated with myocardial infarction. It has also been established a statistically significant connection exists between the risk of myocardial infarction and the presence of allele A (minor allele) of the polymorphism. Allele G, however, has a statistically significant association with the absence of myocardial infarction. All humans-homozygotes with the minor allele A had suffered from myocardial infarction. In the control group, humans-homozygotes with the minor allele A were not found. Conclusion Conclusions: Summarizing our obtained results, we assume the carriers of G/G genotype to have a minimal risk of myocardial infarction onset, the carriers of G/A genotype to have a moderate risk and the carriers of A/A to have a great risk. |
Databáze: | OpenAIRE |
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