Neuronal and non-neuronal modulation of sympathetic neurovascular transmission
| Autor: | Thomas C. Westfall, Gerald H. Wilken, Heather Macarthur, Lacy L. Kolo |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Sympathetic nervous system Physiology Biology Neurotransmission Neuropeptide Y receptor Angiotensin II Nitric oxide chemistry.chemical_compound medicine.anatomical_structure Endocrinology chemistry Internal medicine medicine Premovement neuronal activity Serotonin Endothelin receptor Neuroscience |
| Zdroj: | Acta Physiologica. 203:37-45 |
| ISSN: | 1748-1708 |
| DOI: | 10.1111/j.1748-1716.2010.02242.x |
| Popis: | Noradrenaline, neuropeptide Y and adenosine triphosphate are co-stored in, and co-released from, sympathetic nerves. Each transmitter modulates its own release as well as the release of one another; thus, anything affecting the release of one of these transmitters has consequences for all. Neurotransmission at the sympathetic neurovascular junction is also modulated by non-sympathetic mediators such as angiotensin II, serotonin, histamine, endothelin and prostaglandins through the activation of specific pre-junctional receptors. In addition, nitric oxide (NO) has been identified as a modulator of sympathetic neuronal activity, both as a physiological antagonist against the vasoconstrictor actions of the sympathetic neurotransmitters, and also by directly affecting transmitter release. Here, we review the modulation of sympathetic neurovascular transmission by neuronal and non-neuronal mediators with an emphasis on the actions of NO. The consequences for co-transmission are also discussed, particularly in light of hypertensive states where NO availability is diminished. |
| Databáze: | OpenAIRE |
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