Differential expression of MSX2 in nodular hyperplasia, high-grade prostatic intraepithelial neoplasia and prostate adenocarcinoma
| Autor: | Yong-Chuan Wong, Yung-Tuen Chiu, Ming-Tat Ling, Kwok Wah Chan, Chee-Wai Chua, Hiu-Fung Yuen, Xianghong Wang |
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| Rok vydání: | 2010 |
| Předmět: |
Microbiology (medical)
PCA3 Oncology Intraepithelial neoplasia medicine.medical_specialty business.industry Cancer Bone metastasis General Medicine Hyperplasia medicine.disease Pathology and Forensic Medicine Metastasis Prostate cancer Internal medicine medicine Immunology and Allergy High-grade prostatic intraepithelial neoplasia business |
| Zdroj: | APMIS. 118:918-926 |
| ISSN: | 0903-4641 |
| Popis: | One of the common features in advanced prostate cancer is bone metastasis. In this study, we investigated the clinical relevance of a bone factor, MSX2, in predicting the metastatic ability of prostate adenocarcinoma. Evaluation of MSX2 expression was performed using prostate cell lines as well as patient specimens. A sharp decrease in MSX2 was found in primary prostate cancer cells, 22Rv1, when compared with the non-malignant counterparts, followed by a gradual increase in more aggressive prostate cancer cell lines. Interestingly, the MSX2 protein was upregulated and predominantly expressed in the nucleus in aggressive prostate cancer cell line, C4-2b, compared with the less aggressive 22Rv1. Consistent with the in vitro results, MSX2 nuclear expression was significantly higher in nodular hyperplasia when compared with high-grade prostatic intraepithelial neoplasia (PIN), while MSX2 nuclear expression in prostate adenocarcinoma was higher than that in high-grade PIN. Importantly, MSX2 expression was increased significantly in tumors with metastasis compared with those without metastasis. Finally, MSX2 nuclear scores were significantly increased in patients with preoperative serum PSA >20 ng/mL. No correlation between MSX2 nuclear score and Gleason score was found. Taken together, MSX2 may serve as a potential biomarker in predicting primary prostate tumors with higher metastatic capability. |
| Databáze: | OpenAIRE |
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