The Grade of Acute Thymus Involution in Neonates Correlates with the Duration of Acute Illness and with the Percentage of Lymphocytes in Peripheral Blood Smear

Autor:	Zana Saratlija-Novaković, Merica Glavina-Durdov, Miroslava Barle, Damir Rozić, Oskar Springer, Vesna Ćapkun
Rok vydání:	2003
Předmět:	business.industry Lymphocyte Gestational age Disease Peripheral blood Acute illness medicine.anatomical_structure Intensive care Pediatrics Perinatology and Child Health Immunology medicine Involution (medicine) business Pathological Developmental Biology
Zdroj:	Neonatology. 83:229-234
ISSN:	1661-7819 1661-7800
Popis:	In various stressful conditions, the thymus is subjected to incidental involution, mostly due to the thymocytolytic effect of secreted glucocorticosteroids. The aim of this study was to examine acute thymic involution in sick neonates and to compare the morphological grade with some clinical and laboratorial parameters. The influence of the illness on thymus tissue was investigated in 100 neonates who were treated and died in a neonatology intensive care unit. The preterm infants (n = 73) were born before the 37th week of gestation. Analysis of 57 placentas showed inflammation in 32% and circulatory disturbances in 23% of the cases. The causes of death were confirmed by autopsy: 35 were preterm infants with respiratory distress syndrome without infection, 22 were malformed, and 10 had birth trauma or asphyxia. In contrast, 29 of the preterm infants had an infection, mostly pneumonia or sepsis, and 4 of the term infants had such infections. Acute thymus involution was histologically graded (0–4) according to the method of van Baarlen (see text). Resting state (grade 0) was found in 25 of 38 neonates who lived
Databáze:	OpenAIRE
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