Portable oral cancer detection using a miniature confocal imaging probe with a large field of view
Autor: | H. Stan McGuff, Milan Raj, Bin Yang, Xiaojing Zhang, Youmin Wang, Ting Shen, Gauri Bhave |
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Rok vydání: | 2012 |
Předmět: |
Microelectromechanical systems
Large field of view Scanner Materials science business.industry Mechanical Engineering Confocal education Cancer detection Electronic Optical and Magnetic Materials Lissajous curve Optics Confocal imaging Mechanics of Materials Electrical and Electronic Engineering business Microscope imaging |
Zdroj: | Journal of Micromechanics and Microengineering. 22:065001 |
ISSN: | 1361-6439 0960-1317 |
Popis: | We demonstrate a MEMS micromirror enabled handheld confocal imaging probe for portable oral cancer detection, where a comparatively large field of view (FOV) was generated through the programmable Lissajous scanning pattern of the MEMS micromirror. Miniaturized handheld MEMS confocal imaging probe was developed, and further compared with the desktop confocal prototype under clinical setting. For the handheld confocal imaging system, optical design simulations using CODE VR® shows the lateral and axial resolution to be 0.98 µm and 4.2 µm, where experimental values were determined to be 3 µm and 5.8 µm, respectively, with a FOV of 280 µm×300 µm. Fast Lissajous imaging speed up to 2 fps was realized with improved Labview and Java based real-time imaging software. Properties such as 3D imaging through autofocusing and mosaic imaging for extended lateral view (6 mm × 8 mm) were examined for carcinoma real-time pathology. Neoplastic lesion tissues of giant cell fibroma and peripheral ossifying fibroma, the fibroma inside the paraffin box and ex vivo gross tissues were imaged by the bench-top and handheld imaging modalities, and further compared with commercial microscope imaging results. The MEMS scanner-based handheld confocal imaging probe shows great promise as a potential clinical tool for oral cancer diagnosis and treatment. |
Databáze: | OpenAIRE |
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