| Autor: |
E. A. Alstead, J. A. Morris, D. J. Allison, S. Levi, Bernard Clarke, Humphrey Hodgson, M.J.C. Ellis, M. O. Coupe |
| Rok vydání: |
1989 |
| Předmět: |
|
| Zdroj: |
QJM: An International Journal of Medicine. |
| ISSN: |
1460-2393 |
| DOI: |
10.1093/oxfordjournals.qjmed.a068389 |
| Popis: |
The clinical course and results of drug treatment for manifestations of the carcinoid syndrome are reviewed in 63 patients. The five-year actuarial survival in this group of patients was 48 per cent. The only markers of a poor prognosis that could be identified at diagnosis were marked weight loss and a high (over 1000 mumol/day) 5-hydroxyindole acetic acid excretion. The relative effectiveness of well-established drugs that either block 5-hydroxytryptamine synthesis or block 5-hydroxytryptamine receptors is reported, with respect to the different manifestations of the syndrome, and compared with a small group of patients treated with long-acting somatostatin analogue. In over one-third of patients, primary tumours were not detected on initial investigation, and in none of these did symptoms referrable to the primary site become apparent later. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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