Drawn aligned polymer microfibres for tissue engineering
| Autor: | Michal Řezanka, Lukáš Stanislav, Věra Jenčová, Ilona Krabicová, David Lukas, Kateřina Strnadová, Jan Lukášek, Filip Sabol |
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| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Fabrication Materials science Polymers and Plastics Materials Science (miscellaneous) Nanotechnology 02 engineering and technology Polymer 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Industrial and Manufacturing Engineering 0104 chemical sciences Extracellular matrix chemistry Tissue engineering Chemical Engineering (miscellaneous) 0210 nano-technology |
| Zdroj: | Journal of Industrial Textiles. 50:263-277 |
| ISSN: | 1530-8057 1528-0837 |
| Popis: | Oriented fibres and materials based on orientated fibres have great potential for use in tissue engineering for tissues, where the arrangement of extracellular matrix is fundamental. The drawing method is based on mechanical pulling of a polymer solution out of its base droplet, resulting in a solidified fibre of determined geometrical characteristics. A new machine designed for lab scale drawing was invented enabling a repeatable quality of drawing conditions. The results demonstrate that it is possible to influence and define the fibre diameter and its distribution. From the in vitro experiments, it is evident that the aligned fibres guide the cell growth in the direction of the fibres. Moreover, the prepared fibres were functionalised with polypyrrole as an example of their versatility. These features make drawing an easy and suitable tool for the fabrication of scaffolds with a precise structure for tissues, e.g. nerve tissue. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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