Design and syntheses of 4-acylaminopyridine derivatives: Novel high affinity choline uptake enhancers II

Autor:	Yasuhiro Morinaka, Haruyuki Chaki, Reiko Tabata, Akihiro Tobe, Mitsuo Egawa, Shuji Morita, Haruko Yamabe, Tomoko Bessho, Kenichi Saito, Mamoru Sugano
Rok vydání:	1995
Předmět:	Chemistry Stereochemistry Organic Chemistry Clinical Biochemistry Choline uptake Pharmaceutical Science Biochemistry Group (periodic table) Drug Discovery Molecular Medicine Moiety Organic chemistry Enhancer Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 5:1495-1500
ISSN:	0960-894X
DOI:	10.1016/0960-894x(95)00242-l
Popis:	4-Acylaminopyridine derivatives were synthesized and found to have high affinity choline uptake improvement activity. Optimum activity was obtained when the n-propylcarbonyl group was introduced as the acyl moiety. A series of 2-oxo-1-pyrrolidineacetyl substituted derivatives also showed activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fab18abecef451deedd24551aeab9dbc https://doi.org/10.1016/0960-894x(95)00242-l Zobrazit plný text záznamu Full Text from ScienceDirect