Enantioselective synthesis of a pyrrolo-benzothiadiazine derivative S 18986, a new AMPA receptor positive modulator
| Autor: | P. Morain, Bernard Serkiz, Jean Lepagnol, Alex Cordi, P. Desos |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Reducing agent
Stereochemistry S-18986 Organic Chemistry Clinical Biochemistry Enantioselective synthesis Pharmaceutical Science AMPA receptor Biochemistry chemistry.chemical_compound chemistry Benzothiadiazine Drug Discovery Molecular Medicine Stereoselectivity Enantiomer Molecular Biology Derivative (chemistry) |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 6:3003-3008 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(96)00547-1 |
| Popis: | Enantioselective reduction of pyrrolo-benzothiadiazine 6 using various chiral reducing agents has been studied and led to efficient synthesis of 8 (S 18986) which was established to be of (S) configuration by single crystal X-ray diffraction analysis. S 18986 is a potent and selective AMPA positive modulator which displays total stereoselectivity, the (R) enantiomer being completely inactive. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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