Childhood obesity, renal injury and future disease risk

Autor:	M Lateva, Yoto Yotov, Veselin Boyadzhiev, Dimitrichka Bliznakova, Galina Yordanova, Violeta Iotova, Sonya Galcheva, Nikolay Conev, Yana Bocheva, Maria Neshkinska, Vilhelm Mladenov, Irina Halvadzhiyan
Rok vydání:	2017
Předmět:	Kidney medicine.medical_specialty business.industry Renal function Kidney Volume medicine.disease Gastroenterology Childhood obesity medicine.anatomical_structure Internal medicine Medicine Microalbuminuria business Hyperinsulinism Glomerular hyperfiltration Kidney disease
Zdroj:	Scripta Scientifica Medica. 49:38
ISSN:	1314-6408 0582-3250
DOI:	10.14748/ssm.v49i1.2050
Popis:	INTRODUCTION : Evidence associates obesity with glomerular hyperfiltration. Concurrent inflammation, hypertension, dyslipidemia, and insulin resistance represent further established risks to renal health in both children and adults. Our aim was to investigate the relationship between childhood obesity and the risk of renal impairment. MATERIALS AND METHODS : A total of 114 obese but otherwise healthy children, who were investigated in 2013, were included in the study (mean age 11.5±3.6). Auxology was measured using standard procedures. The pubertal status was defined applying the Tanner scale. Blood and urine tests were performed after overnight fast. Kidney size was measured by standard abdominal ultrasound; kidney volume and estimated glomerular filtration rate were calculated. RESULTS : Microalbuminuria was detected in 8.5% of the children, and 40.2% of all patients were with high systolic blood pressure (BP). Close to half of the children (43.4%) showed insulin resistance (assessed by HOMA-IR) and 95.4% displayed hyperinsulinism. Kidney volume correlated with waist circumference (WC) (left r=0.636, p
Databáze:	OpenAIRE
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