Mitogenic action of mouse anti-isologous aggregated immunoglobulin serum factor on spleen cell proliferation

Autor:	Kirkin Af, Kaulen Dr, Snegireva Ae, V. V. Khorobrykh, O. S. Merimskaya
Rok vydání:	1980
Předmět:	Serial dilution biology Cell growth Spleen General Medicine Molecular biology General Biochemistry Genetics and Molecular Biology In vitro Transplantation medicine.anatomical_structure Immunity Concanavalin A otorhinolaryngologic diseases medicine biology.protein Antibody
Zdroj:	Bulletin of Experimental Biology and Medicine. 89:193-195
ISSN:	1573-8221 0007-4888
Popis:	The effect of mouse serum obtained on the 6th day after injection of isologous aggregated immunoglobulin (MAAS) on proliferative activity of spleen cells was studied in vitro. MAAS was shown to have a weak stimulating action on the cells in dilutions of 1∶40–1∶60, with maximal activity after 48 h; MAAS in these dilutions also potentiates the response of the cells to phytohemagglutinin (PHA) and concanavalin A (Con A). The potentiating effect of MAAS on Con A was stronger, indicating that it acts on cells carrying an Fc-receptor for immunoglobulin on its surface, on which the MAAS factor porbably acts. The nature of the MAAS factor and its possible identity with the factor secreted during treatment of cells with aggregated immunoglobulin in vitro is discussed. The results agree with the hypothesis put forward previously that the effect of MAAS factor on antitumor transplantation immunity may be linked with its mitogenic action.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::faa3fdbb178522b102171ef57b36f963 https://doi.org/10.1007/bf00831020 Zobrazit plný text záznamu Full text from SpringerLink