Synthesis and Anthelmintic Activity of N-Benzylidenepyridin-4-amines

Autor:	Satyajit Dutta
Rok vydání:	2014
Předmět:	Pharmacology Chemistry Death time Pharmacology toxicology Carbon-13 NMR Toluene Albendazole chemistry.chemical_compound Drug Discovery medicine Proton NMR Organic chemistry Anthelmintic Piperazine Citrate medicine.drug Nuclear chemistry
Zdroj:	Pharmaceutical Chemistry Journal. 48:448-451
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-014-1129-0
Popis:	A series of N-benzylidenepyridin-4-amines (1a–1j) were synthesized by refluxing 4-aminopyridine with various substituted aromatic aldehydes in toluene. The structures of the synthesized compounds were confirmed on the basis of IR, 1H NMR, 13C NMR, and mass spectroscopy data. The synthesized compounds were screened for anthelmintic activity on earth worms. Tested compounds showed paralysis time from 0.44 to 2.46 min and death time from 1.03 to 3.50 min, whereas the standard drugs albendazole and piperazine citrate showed paralysis time of 0.54 and 0.58 min and death time of 2.16 and 2.47 min, respectively, at the same concentration of 1 % m/V. Three compounds, including N-(2-hydroxybenzylidene)pyridin-4-amine (1e), N-(4-nitrobenzylidene)pyridin-4-amine (1h), and N-(4-methoxybenzylidene)pyridin-4-amine (1j), showed significant anthelmintic activity compared to the standard drugs.
Databáze:	OpenAIRE
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