Contextual control of skin immunity and inflammation by Corynebacterium
| Autor: | Samira Tamoutounour, Michael A. Fischbach, Y. Erin Chen, Michael G. Constantinides, Nicolas Bouladoux, Yasmine Belkaid, E. Merrill, Jan Claesen, Allyson L. Byrd, Vanessa K. Ridaura |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
biology T cell Immunology Corynebacterium Interleukin Inflammation Corynebacterium accolens biology.organism_classification Microbiology 03 medical and health sciences 030104 developmental biology Immune system medicine.anatomical_structure Immunity medicine Immunology and Allergy Skin immunity medicine.symptom |
| Zdroj: | Journal of Experimental Medicine. 215:785-799 |
| ISSN: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.20171079 |
| Popis: | How defined microbes influence the skin immune system remains poorly understood. Here we demonstrate that Corynebacteria, dominant members of the skin microbiota, promote a dramatic increase in the number and activation of a defined subset of γδ T cells. This effect is long-lasting, occurs independently of other microbes, and is, in part, mediated by interleukin (IL)-23. Under steady-state conditions, the impact of Corynebacterium is discrete and noninflammatory. However, when applied to the skin of a host fed a high-fat diet, Corynebacterium accolens alone promotes inflammation in an IL-23–dependent manner. Such effect is highly conserved among species of Corynebacterium and dependent on the expression of a dominant component of the cell envelope, mycolic acid. Our data uncover a mode of communication between the immune system and a dominant genus of the skin microbiota and reveal that the functional impact of canonical skin microbial determinants is contextually controlled by the inflammatory and metabolic state of the host. |
| Databáze: | OpenAIRE |
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