Composition and antimalarial activity of extracts of Curcuma longa L. obtained by a combination of extraction processes using supercritical CO2, ethanol and water as solvents
| Autor: | Pedro Melillo de Magalhães, Ana Carolina A. V. Kayano, Carmen L. Queiroga, Fabio T. M. Costa, Fernando A. Cabral, Hugo A. Martinez-Correa, Julia T. Paula |
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| Rok vydání: | 2017 |
| Předmět: |
Supercritical carbon dioxide
Chromatography Ethanol biology 010405 organic chemistry Chemistry Stereochemistry General Chemical Engineering 010401 analytical chemistry Extraction (chemistry) Water extraction Condensed Matter Physics biology.organism_classification 01 natural sciences Supercritical fluid 0104 chemical sciences Solvent chemistry.chemical_compound Yield (chemistry) Physical and Theoretical Chemistry Curcuma |
| Zdroj: | The Journal of Supercritical Fluids. 119:122-129 |
| ISSN: | 0896-8446 |
| Popis: | Rhizome of Curcuma longa L. is rich in curcumin which is also an important natural pigment and has important biological activity. In order to obtain curcumin concentrated extracts, one-step and two-step processes were employed. The one step process involves supercritical carbon dioxide (scCO 2 ) at 60 °C and 400 bar, ethanol at 25 °C and water at 60 °C, both at atmospheric pressure. Ethanol and/or water were used as solvents. In the two-step process, sequential extraction, using scCO 2, was performed followed by ethanol or water extraction. All the extracts obtained were analyzed and results were reported for global extraction yield, the total phenolic content, total flavonoids, curcumin, antimalarial activity and antioxidant activity. The two-step process showed the highest global yield (23.4%) when water is used as solvent in the second step. However, high concentrations of curcumin and high antioxidant activity were obtained when ethanol is used as solvent. The supercritical extract presents low concentration of curcumin and high antimalarial activity; which shows that extracts of different compositions and functionality can be obtained from a sequential extraction. |
| Databáze: | OpenAIRE |
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