Effect of Alcohol Intake on Human Apolipoprotein A-I—Containing Lipoprotein Subfractions
| Autor: | Gecel Zylberberg, C. Demarquilly, Nordine Ghalim, Pierre Fievet, Jean Charles Fruchart, P. Puchois |
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| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Very low-density lipoprotein Apolipoprotein B biology business.industry Human apolipoprotein Coronary Artery Disease Risk medicine.disease Coronary artery disease Endocrinology Internal medicine Internal Medicine medicine biology.protein lipids (amino acids peptides and proteins) Alcohol intake Apolipoprotein C2 biological phenomena cell phenomena and immunity business Lipoprotein |
| Zdroj: | Archives of Internal Medicine. 150:1638 |
| ISSN: | 0003-9926 |
| DOI: | 10.1001/archinte.1990.00040031638010 |
| Popis: | High-density lipoprotein comprises two main types of lipoprotein particles: (1) those that contain apolipoproteins A-I and A-II, designated LpA-I:A-II, and (2) those that contain apolipoprotein A-I but not apolipoprotein A-II, designated LpA-I. Both have been extensively studied and are believed to represent distinct metabolic entities that may confer differing protection against coronary artery disease risk. We have previously suggested that LpA-I might represent the antiatherogenic effect, which has been ascribed mainly to its effect on high-density lipoprotein cholesterol; we set out to investigate, in 344 men, the relation between LpA-I:A-II and LpA-I levels and alcohol consumption. As the alcohol intake rose, LpA-I:A-IIII levels increased, while LpA-I levels fell. On the assumption that LpA-I is the antiatherogenic fraction of high-density lipoprotein, the putative protective action of alcohol consumption against coronary artery disease should be reconsidered. ( Arch Intern Med. 1990;150:1638-1641) |
| Databáze: | OpenAIRE |
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