Engineering a CD4 mimetic inhibiting the binding of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein gp120 to human lymphocyte CD4 by the transfer of a CD4 functional site to a small natural scaffold

Autor:	Jean Vizzavona, Claudio Vita, Eugenia Drakopoulou
Rok vydání:	1998
Předmět:	chemistry.chemical_classification Scaffold Human lymphocyte Charybdotoxin Pharmacology toxicology Human immunodeficiency virus (HIV) medicine.disease_cause Hiv 1 envelope Biochemistry Amino acid chemistry.chemical_compound chemistry medicine Glycoprotein
Zdroj:	Letters in Peptide Science. 5:241-245
ISSN:	1573-496X 0929-5666
Popis:	The solvent-exposed CDR2-like region of human CD4 was transferred to the structural scaffold of scorpion charybdotoxin, as a means to reproduce that site in a native-like conformation. The chimeric mini-protein (33 amino acids long), obtained by solid-phase synthesis, is able to specifically prevent the interaction of HIV-1 gp120 with CD4. This CD4 mimetic may represent a valuable tool in the study of the HIV-cell interactions and as a lead in the development of antiviral drugs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fa9a6e2bc5ae452eb6b88113911d8299 https://doi.org/10.1007/bf02443476 Zobrazit plný text záznamu Full text from SpringerLink