Double catalytic enantioselective Michael addition reactions of tertiary nucleophile precursors—tertiary/quaternary and quaternary/quaternary carbon–carbon bond formations

Autor:	Shuji Kanemasa, Kazuhiro Kodama, Hiroshi Yanagita
Rok vydání:	2006
Předmět:	Chemistry Organic Chemistry Chiral ligand Cationic polymerization Enantioselective synthesis Alcohol Biochemistry Medicinal chemistry Catalysis Metal chemistry.chemical_compound Nucleophile visual_art Drug Discovery Michael reaction visual_art.visual_art_medium Organic chemistry
Zdroj:	Tetrahedron Letters. 47:9353-9357
ISSN:	0040-4039
Popis:	Enantioselective Michael addition reactions of tertiary nucleophile precursors, such as substituted malononitriles and cyclic 1,3-diketones, can be successfully activated by the metal complexes derived from R,R-DBFOX/Ph chiral ligand and cationic metal salts. With this method, the enantioselective tertiary/quaternary and quaternary/quaternary carbon–carbon bond formations can be achieved. Use of alcohol solvents is essential for the success, and α,β-unsaturated amides of 3,5-dimethylpyrazole are much better acceptors than those of 2-oxazolidinone.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fa99c9425f4e4eb46e75d98e41b1271a https://doi.org/10.1016/j.tetlet.2006.10.089 Zobrazit plný text záznamu Full Text from ScienceDirect