An evaluation of whole blood testing for Helicobacter pylori infection in the Chinese population

Autor:	Ching-Lung Lai, C. K. Chan, Vsy Tang, George K. K. Lau, Bcy Wong, Kam Chuen Lai, Wai Man Wong, SK Lam, Whc Hu, S. T. Yuen
Rok vydání:	2000
Předmět:	Breath test medicine.medical_specialty Hepatology medicine.diagnostic_test biology business.industry Gastroenterology Rapid urease test Gold standard (test) Helicobacter pylori biology.organism_classification Surgery Predictive value of tests Internal medicine Biopsy Medicine Pharmacology (medical) business Prospective cohort study Whole blood
Zdroj:	Alimentary Pharmacology & Therapeutics. 14:331-335
ISSN:	0269-2813
DOI:	10.1046/j.1365-2036.2000.00704.x
Popis:	Background: Near patient tests for Helicobacter pylori were developed to assist in the management of dyspepsia patients in general practice. Most studies were performed in western populations. Aim: To evaluate the rapid whole blood test (Flexpack HP) for H. pylori in the Chinese population. Methods: Consecutive dyspeptic patients referred for upper endoscopy were recruited. During upper endoscopy, biopsies were taken from the antrum and corpus for rapid urease test (CLO test) and histological examination. After endoscopy, the whole blood test (FlexPack HP) was performed according to the manufacturer’s instruction. Patients then received a 13C-urea breath test. Results of the whole blood test were compared with the gold standard (CLO test, histology and 13C-urea breath test). Results: A total of 294 consecutive patients gave a valid Flexpack HP result for interpretation. The mean age of patients was 47.7 (range 15–85) years. Analysis showed a sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 58%, 92%, 91%, 63% and 73% respectively. Conclusion: The FlexPack HP whole blood test showed good specificity but lacked sensitivity. It is not sensitive enough to be used in a general practice setting for the test-and-treat approach in the Chinese population.
Databáze:	OpenAIRE
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