The relationship between the type I interferon signature and the response to rituximab in rheumatoid arthritis
| Autor: | R M Thurlings, M Boumans, J Tekstra, K Vos, D M van Westing, L G van Baarsen, C Bos, K A Kirou, D M Gerlag, M K Crow, C L Verweij, P P Tak |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Ifn response
business.industry Immunology medicine.disease Peripheral blood mononuclear cell General Biochemistry Genetics and Molecular Biology Disease activity Rheumatology immune system diseases Interferon Rheumatoid arthritis Cohort medicine Immunology and Allergy Rituximab business medicine.drug |
| Zdroj: | Annals of the Rheumatic Diseases. 69:A14-A15 |
| ISSN: | 0003-4967 |
| DOI: | 10.1136/ard.2010.129585k |
| Popis: | To analyse the relationship between the type I interferon (IFN) signature and the response to rituximab in rheumatoid arthritis (RA) patients. Twenty RA patients were treated with rituximab (cohort 1). As a read out for clinical response the decrease in disease activity score (DAS28) between week 0 and 24 was used. In peripheral blood mononuclear cells from baseline the presence of an IFN signature was analysed by measuring the expression levels of three IFN response genes … |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|