Purine metabolism in Mycobacterium leprae grown in armadillo liver

Autor:	Saroj R. Khanolkar, Paul R. Wheeler
Rok vydání:	1983
Předmět:	Purine Bacilli biology Metabolism biology.organism_classification Microbiology In vitro chemistry.chemical_compound Biochemistry chemistry Genetics Nucleic acid Purine metabolism Molecular Biology Mycobacterium leprae Bacteria
Zdroj:	FEMS Microbiology Letters. 20:273-278
ISSN:	1574-6968 0378-1097
DOI:	10.1111/j.1574-6968.1983.tb00131.x
Popis:	Mycobacterium leprae organisms generally incorporated purines more rapidly than pyrimidines into nucleic acids from the incubation medium. Purine synthesis de novo took place at a very slow rate suggesting a preference of the organism for preformed purines. In cell-free extracts of leprosy bacilli, enzyme for scavenging and interconversion of purines were detected. The results are discussed in the light of the failure to cultivate M. leprae in vitro, and the use of labelled substrates to determine the viability of suspensions of leprosy bacilli and their sensitivity to anti-leprosy drugs.
Databáze:	OpenAIRE
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